In Dr. Hymel's doctoral dissertation study, SA circuit designs, developed specifically for electrocardiology, the electrical functioning of the heart, underwent rigorous refinement, testing and evaluation. In the study, the 'negative delay' (temporal advance) of the analog signals achieved with SAT was investigated and the results analyzed with respect to the temporal advance achieved as well as the fidelity of the temporally-advanced output signals. The research project, completed in 2010, exceeded all of its objectives, having successfully demonstrated the ability of SAT to temporally advance a range 'known' constructed test signals (pulses and sine waves) and human electrocardiographic (ECG) signals (heart beats) from cardiac patients. The project resulted in a doctorate dissertation (Hymel CM, Application of Signal Advance Technology to Electrophysiology, University of Texas Health Science Center - Houston, Graduate School of Biomedical Sciences, August 2010), which was downloaded over 100 times within the first year of publication.
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Dr. Hymel's Ph.D. supervisory committee was tasked with oversight, critical review, and ultimate approval of the multi-year research project. An absolute requirement for that approval of such a dissertation is novelty. The supervisory committee that extensively reviewed and confirmed the project results and ultimately approved the dissertation was comprised of university faculty including two electrical engineers, two physicists, a neurophysiologist and a biomedical scientist. Two former University of Texas - Houston faculty members and one former Baylor College of Medicine faculty member (a physicist, a biomedical engineer and a neurosurgeon) who had previously served on the committee, continued to provide input, assistance and critical reviews of the research. One of these individuals now serves as an SAI director and the other two are members of the SAI advisory board.
The results of the study were summarized in a peer-reviewed engineering article which discusses the theoretical basis, practical implementation and examples of potential applications for SA technology. The manuscript, submitted for review in March 2011, was published as the feature article in the IEEE Circuits and Systems Magazine, in the 3rd Qtr.
(Hymel et al, IEEE Circuits and Systems Magazine, 3Q, 11 (3), 10-25).
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